“Derived Multiple Allogeneic Protein Paracrine Signaling (d-MAPPS)” Enhances T Cell-Driven Immune Response to Murine Mammary Carcinoma

<div>d-MAPPS delayed mammary tumor appearance and inhibited tumor growth. (a) Mean value of time period in days from inoculation of 4T1 breast cancer cells to the appearance of palpable primary tumor in 4T1+saline-treated (black bars) and 4T1+d-MAPPS-treated BALB/c mice (white bars). (b) Percentage of 4T1+saline- and 4T1+d-MAPPS-treated BALB/c mice after 36 days of follow-up. (c) Light-microscopic pictures (magnification, ×10) through liver (upper panels), lung (middle panels), and brain tissue sections (lower panels) showing metastatic colonies (black arrows). (d) Survival of 4T1+saline-treated (blue line) and 4T1+d-MAPPS-treated mice (red line). The mean value of primary tumor (e) volume and (f) weight at day 36. 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Analytical Cellular Pathology

fig1

Figure 1

Figure 1: “Derived Multiple Allogeneic Protein Paracrine Signaling (d-MAPPS)” Enhances T Cell-Driven Immune Response to Murine Mammary Carcinoma 