Chemoprevention of 4NQO-Induced Mouse Tongue Carcinogenesis by AKT Inhibitor through the MMP-9/RhoC Signaling Pathway and Autophagy

<div>Histological examination of mouse tongue mucosa: (a) normal mouse tongue mucosal epithelium; (b) mouse tongue mucosal epithelium with mild to moderate dysplasia; (c) mouse tongue mucosal epithelium with severe dysplasia; (d) mouse tongue mucosal epithelium with invasive squamous cell carcinoma. Magnification ×100; ×400.</div>

Analytical Cellular Pathology

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Figure 3

Figure 3: Chemoprevention of 4NQO-Induced Mouse Tongue Carcinogenesis by AKT Inhibitor through the MMP-9/RhoC Signaling Pathway and Autophagy 