Chemoprevention of 4NQO-Induced Mouse Tongue Carcinogenesis by AKT Inhibitor through the MMP-9/RhoC Signaling Pathway and Autophagy

<div>MK2206 2HCl suppressed cancer cell proliferation in 4NQO-induced mouse tongue tumors. (a) MK2206 2HCl inhibited p-AKT expression in 4NQO-induced mouse tongue tumors. (b) Cell proliferation was suppressed by MK2206 2HCl as showed by Ki67 positive cells. (c) MK2206 2HCl promoted p21 expression in tongue tumors. 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Magnification ×400.</div>

Analytical Cellular Pathology

fig4

Figure 4

Figure 4: Chemoprevention of 4NQO-Induced Mouse Tongue Carcinogenesis by AKT Inhibitor through the MMP-9/RhoC Signaling Pathway and Autophagy 