Research Article
Chemoprevention of 4NQO-Induced Mouse Tongue Carcinogenesis by AKT Inhibitor through the MMP-9/RhoC Signaling Pathway and Autophagy
Table 1
Chemopreventive effect of MK2206 2HCl on 4NQO-induced mouse oral carcinogenesis.
| | Mouse no. | Visible tumor | No. of tumor | Tumor volume (mm3) | Normal mucosa | Mild to moderate dysplasia | Severe dysplasia | Cancer |
| | Blank | 20 | — | — | — | 20 (100%) | — | — | — | | 4NQO+captisol | 18 | 17 (94.4%) | 35 | | — | 3 (16.7%) | 2 (11.1%) | 13 (72.2%) | | 4NQO+MK2206 2HCl | 19 | 11 (57.9%) | 17 | | — | 4 (21.1%) | 8 (42.1%) | 7 (36.8%) |
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as compared with the 4NQO+captisol group. |
