Magnetic Resonance Imaging of Contrast-Induced Acute Renal Injury and Related Pathological Alterations In Vivo

Figure 1

Overall experiment design and ROIs. All the mice were 7-8 w male C57BL/6. Baseline fMRI was performed on 15 randomly chosen mice. After a 24-hour fasting and dehydration, CM injection was performed on these 15 mice and saline injection was performed on 3 randomly chosen control mice. At five different times, fMRI was performed on every 3 randomly chosen mice of CM injection and the kidneys and blood were taken for further study. Another 2 mice were given CM injection the same as before, and the kidneys were taken at 48 h for TEM. Two ROIs were measured, the red region CO represents the cortex, and the blue region ME represents the medulla. fMRI: functional magnetic resonance imaging; CM: contrast media; TEM: transmission electron microscope.