Magnetic Resonance Imaging of Contrast-Induced Acute Renal Injury and Related Pathological Alterations In Vivo

Figure 4

Renal microscopic H&E images. The upper row of each group presents the renal cortex (CO) and the second row presents the renal medulla (ME). (a) CM for 1 h, swollen and shedding tubular epithelium (arrows). (b) CM for 12 h, cytoplasmic vacuoles (stars) in tubular epithelium and shedding vacuolated cells (stars) budged into the lumen. (c) CM for 24 h, nuclei desquamated from tubular epithelium (arrows). (d) CM for 48 h, cast appeared (triangles). (e) CM for 72 h, cytoplasmic vacuoles (stars) and cast (triangles) disappeared gradually. (f) Saline for control, some shedding tubular epithelium (arrows). (g) Histological score of the kidney shows renal injury began at 1 h and recovered at 24 h after CM injection; , , and . Original magnification: 50x, 100x, and 400x.

(a) H&E for 1 h CM

(b) H&E for 12 h CM

(c) H&E for 24 h CM

(d) H&E for 48 h CM

(e) H&E for 72 h CM

(f) H&E for control

(g) Time (h)