Transcription Factor E2F1 Exacerbates Papillary Thyroid Carcinoma Cell Growth and Invasion via Upregulation of LINC00152

Figure 4

LINC00152 regulates PTC cell growth and invasion via the PI3K/AKT axis. Initially, 10 μM LY294002 was added into IHH-4 cells to conduct pretreatment for 2 h. (a) Levels of the PI3K/AKT axis-related proteins (PI3K, p-PI3K, AKT, and p-AKT) verified through Western blot analysis. (b, c) Cell proliferation detected by (b) CCK-8 and (c) colony formation assay. (d) Cell migration and invasion measured through Transwell assay. . Data are expressed as . The -test was used for pairwise comparison. One-way ANOVA was used to determine statistical significance. Tukey’s multiple comparisons test was applied for post hoc test. ; ; .

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