Effect of Lycium barbarum Polysaccharide on Decreasing Serum Amyloid A3 Expression through Inhibiting NF-κB Activation in a Mouse Model of Diabetic Nephropathy

Figure 4

LBP inhibited the proinflammatory cytokine expression in diabetic mice: (a) the mRNA levels of TNFα, IL1b, IL6, and SAA3 in the kidney cortex; (b) the plasma level of SAA3; (c) the immunohistochemical analysis of SAA3 deposition in tubulointerstitium and glomerulus; (d) the quantification of SAA3 in the kidney by immunostaining scores. Data are expressed as the (-9 mice per group). Control vs. other groups, ; ^#diabetic group vs. other groups, ; ^$MET vs. LBP, ; ns means no significance.