Mesenchymal Stem Cells and their Derived Exosomes Promote Malignant Phenotype of Polyploid Non-Small-Cell Lung Cancer Cells through AMPK Signaling Pathway

<div>MSCs and MSC-exosomes reduced apoptosis and promoted autophagy in the polyploid A549 and H1299 cells. (a, b) Apoptosis analysis of the polyploid A549 and H1299 cells following coculture with MSC-CM, MSCs, and MSC-exosomes was examined by flow cytometry at 48 hours. (c) Stained with anti-LC3A/B antibody to detect the LC3 puncta and DAPI to detect nuclei by immunofluorescence using a fluorescence microscope (×200).</div>

Analytical Cellular Pathology

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Figure 5

Figure 5: Mesenchymal Stem Cells and their Derived Exosomes Promote Malignant Phenotype of Polyploid Non-Small-Cell Lung Cancer Cells through AMPK Signaling Pathway 

Figure 5 | Mesenchymal Stem Cells and their Derived Exosomes Promote Malignant Phenotype of Polyploid Non-Small-Cell Lung Cancer Cells through AMPK Signaling Pathway 