Mesenchymal Stem Cells and their Derived Exosomes Promote Malignant Phenotype of Polyploid Non-Small-Cell Lung Cancer Cells through AMPK Signaling Pathway

<div>MSCs and MSC-exosomes activated AMPK signaling pathway in the polyploid A549 and H1299 cells. (a, b) Protein levels of MMP-9, Bcl-xl, Bak, LC3A/B, P62, AMPK, and phospho-AMPK (Thr172) in the polyploid A549 and H1299 cells following coculture with MSC-CM, MSCs, and MSC-exosomes were determined by Western blot analysis.</div>

Analytical Cellular Pathology

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Figure 6

Figure 6: Mesenchymal Stem Cells and their Derived Exosomes Promote Malignant Phenotype of Polyploid Non-Small-Cell Lung Cancer Cells through AMPK Signaling Pathway 

Figure 6 | Mesenchymal Stem Cells and their Derived Exosomes Promote Malignant Phenotype of Polyploid Non-Small-Cell Lung Cancer Cells through AMPK Signaling Pathway 