Metabolomics-Based Pharmacodynamic Analysis of Zhuang Yao Shuang Lu Tong Nao Granules in a Rat Model of Ischemic Cerebral Infarction

Table 3

Differential metabolites in serum samples.

Number	Metabolites	Molecular formula	RT (min)	value			Fold change
				MACO_R/NC	MACO_R/sham	MACO_R/YHT	MACO_R/NC	MACO_R/sham	MACO_R/YHT
1	Creatine	C4H9N3O2	10.795	<0.001	<0.001	0.043	1.379	1.465	0.939
2	L-Citrulline	C6H13N3O3	11.832	0.001	<0.001	0.005	0.705	0.742	0.717
3	L-Isoleucine	C6H13NO2	8.744	0.008	0.012	0.006	1.257	1.265	0.668
4	SM(d18:1/16:0)	C39H79N2O6P	5.104	0.004	<0.001	0.002	1.238	1.268	0.723
5	Trigonelline	C7H7NO2	9.499	0.024	0.019	<0.001	0.265	0.221	0.179
6	L-Glutamic acid	C5H9NO4	12.589	<0.001	<0.001	0.013	0.410	0.460	0.638
7	4-Guanidinobutyric acid	C5H11N3O2	10.878	0.037	0.018	0.006	0.369	0.307	0.726
8	Guanidineacetic acid	C3H7N3O2	10.949	0.012	0.001	0.001	0.445	0.384	0.224
9	Pyroglutamic acid	C5H7NO3	12.540	<0.001	0.001	0.026	0.425	0.477	0.670
10	Prolylleucine	C11H20N2O3	11.366	0.026	0.001	0.045	1.499	2.079	1.770
11	L-Aspartic acid	C4H7NO4	12.746	<0.001	0.023	0.010	0.305	0.250	0.352
12	Eicosapentaenoic acid	C20H30O2	2.468	0.005	0.015	0.039	0.148	0.165	4.080
13	Sphingosine	C18H37NO2	5.079	0.005	<0.001	0.002	0.238	0.222	2.216
14	Argininosuccinic acid	C10H18N4O6	13.513	0.017	0.004	0.023	0.535	0.555	0.432
15	Arecoline	C8H13NO2	10.695	0.040	0.028	0.002	0.180	0.156	2.200
16	trans-3-Indoleacrylic acid	C11H9NO2	2.538	0.004	0.003	0.043	0.353	0.311	3.577
17	Paracetamol	C8H9NO2	11.158	0.001	0.001	<0.001	2.013	1.780	0.151
18	2-O-Methylguanosine	C11H15N5O5	6.812	0.030	0.011	0.006	0.700	0.691	0.274