Metabolomics-Based Pharmacodynamic Analysis of Zhuang Yao Shuang Lu Tong Nao Granules in a Rat Model of Ischemic Cerebral Infarction

Table 4

Metabolic pathway analysis.

Pathway	Raw	-ln()	FDR	Impact
Arginine and proline metabolism	<0.001	9.258	0.006	0.122
Arginine biosynthesis	<0.001	8.846	0.006	0.462
Glutathione metabolism	0.002	6.037	0.067	0.054
Histidine metabolism	0.004	5.515	0.085	0.000
Sphingolipid metabolism	0.009	4.723	0.149	0.069
Aminoacyl-tRNA biosynthesis	0.017	4.084	0.236	<0.001
Alanine, aspartate, and glutamate metabolism	0.020	3.922	0.238	0.442
Glycine, serine, and threonine metabolism	0.033	3.405	0.349	0.092
Beta-alanine metabolism	0.071	2.642	0.665	0.056
Phenylalanine, tyrosine, and tryptophan biosynthesis	0.082	2.498	0.691	0.500
Nitrogen metabolism	0.121	2.113	0.846	<0.001
D-Glutamine and D-glutamate metabolism	0.158	2.113	0.846	0.500
Valine, leucine, and isoleucine biosynthesis	0.158	1.846	1.000	<0.001
Phenylalanine metabolism	0.228	1.481	1.000	0.357
Butanoate metabolism	0.276	1.287	1.000	<0.001
Nicotinate and nicotinamide metabolism	0.276	1.287	1.000	<0.001
Pantothenate and CoA biosynthesis	0.336	1.090	1.000	<0.001
Porphyrin and chlorophyll metabolism	0.478	0.739	1.000	<0.001
Glyoxylate and dicarboxylate metabolism	0.500	0.693	1.000	<0.001
Biosynthesis of unsaturated fatty acids	0.542	0.613	1.000	<0.001
Pyrimidine metabolism	0.571	0.560	1.000	0.005
Valine, leucine, and isoleucine degradation	0.581	0.544	1.000	<0.001