Extracellular Vesicle-Encapsulated MicroRNA-375 from Bone Marrow-Derived Mesenchymal Stem Cells Inhibits Hepatocellular Carcinoma Progression through Regulating HOXB3-Mediated Wnt/β-Catenin Pathway

Figure 7

Schematic diagram depicting the molecular mechanism of EV-incorporated miR-375 in HCC cell proliferation, migration, and invasion. BM-MSC-derived EV inhibits HCC cell proliferation, migration, and invasion and promotes apoptosis by delivering miR-375 to HCC cells. miR-375 targets and inhibits the expression of HOXB3, thus impairing the downstream Wnt/β-catenin pathway.