The Relationship between MACC1/c-Met/Cyclin D1 Axis Expression and Prognosis in ESCC

Table 6

Univariate analysis of factors associated with OS and PFS in ESCC patients.

Characteristic	OS			PFS
	95% CI		value	95% CI		value
Age (years)
<60/≥60	24.681-37.319 vs. 31.774-48.226	5.360	0.02	13.920-34.080 vs. 14.944-45.056	3.761	0.05
Gender
Male/female	30.714-26.587 vs. 26.587-45.413	0.081	0.78	16.493-31.507 vs. 13.258-48.742	1.077	0.30
Ethnicity
Han/Kazakh	25.206-46.794 vs. 33.988-46.012	0.164	0.67	16.037-31.963 vs. 19.773-42.227	1.136	0.29
Tumor location
Upper/middle/lower	20.088-75.912 vs. 34.733-45.267 vs. 25.607 vs. 40.393	2.183	0.34	0-99.530 vs. 11.042-40.958 vs. 10.175 vs. 37.825	1.063	0.59
Tumor size
<3 cm/≥3 cm	35.063-48.937 vs. 24.025-41.975	4.267	0.04	33.675-46.325 vs. 15.498-24.502	3.908	0.04
Degree of differentiation
Poor/moderate/well	12.573-43.427 vs. 34.313-45.687 vs. 28.959-51.041	6.521	0.04	15.678-20.322 vs. 15.539-32.641 vs. 20.402-99.598	9.072	0.01
Lymph node metastasis
Negative/positive	33.142-48.858 vs. 15.820-24.180	8.730	0.003	29.674-42.326 vs. 6.921-17.079	11.888	0.001
Invasive depth
Mucosa/muscularis/full thickness	0-85.4 vs. 35.377-44.623 vs. 28.313-43.687	0.487	0.78	0-39.4 vs. 17.492-42.508 vs. 16.086-31.914	2.109	0.35
AJCC stage
I/II/III/IV	6.073-65.927 vs. 33.591-48.409 vs. 17.713-22.287 vs. 5.721-54.279	7.261	0.06	0-46.624 vs. 28.118-43.882 vs. 12.85-21.15 vs. 8.911-15.089	9.911	0.02
Vascular invasion
Negative/positive	30.609-41.391 vs. 31.516-48.484	0.274	0.60	15.312-38.688 vs. 11.752-36.248	0.634	0.43
Nerve invasion
Negative/positive	34.737-45.263 vs. 6.270-41.730	5.197	0.02	19.232-40.768 vs. 0-32.479	7.272	0.007
Hematogenous metastasis
Negative/positive	29.139-42.861 vs. 31.769-40.231	0.547	0.46	19.595-40.405 vs. 3.368-36.632	3.407	0.07
MACC1 expression
Negative/positive	27.368-38.632 vs. 25.557-58.443	6.985	0.008	13.556-34.444 vs. 17.052-42.948	1.921	0.17
c-Met expression
Negative/positive	29.822-43.453 vs. 49.128-65.143	21.173	<0.001	12.271-23.729 vs. 28.620-47.740	8.991	0.003
Cyclin D1 expression
Negative/positive	27.638-44.362 vs. 31.777-40.223	0.111	0.74	21.643-48.357 vs. 18.494-29.506	0.302	0.58

Abbreviations: ESCC: esophageal squamous cell carcinoma; AJCC: American Joint Committee on Cancer; OS: overall survival; PFS: progression-free survival.