Research Article
The Relationship between MACC1/c-Met/Cyclin D1 Axis Expression and Prognosis in ESCC
Table 7
Multivariate analysis of factors associated with OS and PFS for ESCC.
| | OS | PFS | | 95% CI | HR | value | 95% CI | HR | value |
| | Age (years) | | | | | | | | <60/≥60 | 1.058-2.290 | 1.566 | 0.03 | — | — | — | | Tumor size | | | | | | | | <3 cm/≥3 cm | 0.403-0.990 | 0.631 | 0.04 | 0.428-1.008 | 0.657 | 0.06 | | Degree of differentiation | | | | | | | | Poor/moderate/well | 0.563-0.998 | 0.746 | 0.04 | 0.511-0.875 | 0.668 | 0.003 | | Lymph node metastasis | | | | | | | | Negative/positive | 1.200-2.685 | 1.795 | 0.004 | 1.307-2.830 | 1.923 | 0.001 | | AJCC stage | | | | | | | | I/II/III/IV | — | — | — | 1.076-1.795 | 1.39 | 0.01 | | Nerve invasion | | | | | | | | Negative/positive | 1.058-2.586 | 1.654 | 0.03 | 1.147-2.638 | 1.739 | 0.009 | | MACC1 expression | | | | | | | | Negative/positive | 0.393-0.884 | 0.589 | 0.01 | — | — | — | | c-Met expression | | | | | | | | Negative/positive | 0.237-0.582 | 0.371 | <0.001 | 0.377-0.829 | 0.559 | 0.004 |
|
|
Abbreviations: ESCC: esophageal squamous cell carcinoma; AJCC: American Joint Committee on Cancer; OS: overall survival; PFS: progression-free survival.
|
