The Relationship between MACC1/c-Met/Cyclin D1 Axis Expression and Prognosis in ESCC

Table 8

Effects of coexpression of MACC1, c-Met, and cyclin D1 on the prognosis of ESCC.

Coexpression	OS		OS		PFS		PFS
	Univariate		Multivariate		Univariate		Multivariate
	Log-rank (Mantel-Cox)	value	95% CI	value	Log-rank (Mantel-Cox)	value	95% CI	value
MACC1, c-Met, and cyclin D1
(+++ vs. ++- vs. +-- vs. ---)	17.946	<0.001	0.605-0.877	0.001	0.449	0.93	—	—
MACC1 and c-Met
(++ vs. +- vs. --)	18.438	<0.001	0.456-0.767	<0.001	6.638	0.04	0.600-0.941	0.01
MACC1 and cyclin D1
(++ vs. +- vs. --)	5.025	0.08	—	—	1.16	0.56	—	—
c-Met and cyclin D1
(++ vs. +- vs. --)	10.932	0.004	0.534-0.878	0.003	0.216	0.90	—	—

Abbreviations: ESCC: esophageal squamous cell carcinoma; OS: overall survival; PFS: progression-free survival; 95% CI: 95% confidence interval.