FOXA1 Leads to Aberrant Expression of SIX4 Affecting Cervical Cancer Cell Growth and Chemoresistance

<div>Overexpression of SIX4 activates the PI3K/AKT signaling pathway to promote CC cell growth and chemoresistance to DDP. (a) Detection of SIX4 mRNA expression in HT-3/DDP and HeLa/DDP cells by RT-qPCR. (b) The proliferation of cells measured using colony formation assay. (c) The cell viability measured using EdU assay. (d) The invasive ability of cells determined using Transwell assay. (e) The chemoresistance of cells to DDP measured using MTT assay. (f) The protein expression of p-PI3K, PI3K, p-AKT, and AKT in cells examined using Western blot. 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Analytical Cellular Pathology

fig4

Figure 4

Figure 4: FOXA1 Leads to Aberrant Expression of SIX4 Affecting Cervical Cancer Cell Growth and Chemoresistance 