Research Article

miR-432-5p Inhibits the Ferroptosis in Cardiomyocytes Induced by Hypoxia/Reoxygenation via Activating Nrf2/SLC7A11 Axis by Degrading Keap1

Table 2

The heart function in rats from sham, NC-Lipo, and miR-432-5p-Lipo groups (N = 6 in each group).

ShamNC-LipomiR-432-5p-Lipo
Before anesthesia4 hr After anesthesiaBefore anesthesia4 hr After anesthesiaBefore anesthesia4 hr After anesthesia

HR391 ± 15338 ± 21382 ± 17402 ± 19, ##
MAP (mm Hg)66.27 ± 3.5248.86 ± 3.8467.58 ± 3.7365.88 ± 3.6739.62 ± 4.13
LVDP (mm Hg)123.4 ± 5.399.6 ± 7.6116.8 ± 4.8112.7 ± 5.2, ##
LVEDP (mm Hg)5.95 ± 1.226.38 ± 1.256.11 ± 1.287.31 ± 1.296.06 ± 2.026.67 ± 2.11

HR, heart rate; MAP, mean arterial pressure; LVDP, left ventricular diastolic pressure; LVEDP, left ventricular end-diastolic pressure. compared to sham, in same time point; ##compared to NO-Lipo, in same time point.