Suppression of lncRNA OIP5-AS1 Attenuates Apoptosis and Inflammation, and Promotes Proliferation by Mediating miR-25-3p Expression in Lipopolysaccharide-Induced Myocardial Injury

<div>OIP5-AS1 directly targets miR-25-3p. (a) The WT binding site of OIP5-AS1 with miR-25-3p was predicted by starBase4.0 and relevant mutant sequence (MUT) was shown. (b) Relative expression of miR-25-3p in cells transfected with shOIP5-AS1 was detected by qRT-PCR. **versus sh-NC. (c) The transfection efficiency of miR-25-3p mimics was detected by qRT-PCR. **versus sh-NC. (d and e) The relationship between OIP5-AS1 and miR-25-3p was validated by luciferase reporter assay (d) and RIP assay (e). (f) The expression relation between OIP5-AS1 and miR-25-3p was determined by Pearson’s correlation analysis. **versus sh-NC.</div>

Analytical Cellular Pathology

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Figure 5

Figure 5: Suppression of lncRNA OIP5-AS1 Attenuates Apoptosis and Inflammation, and Promotes Proliferation by Mediating miR-25-3p Expression in Lipopolysaccharide-Induced Myocardial Injury 

Figure 5 | Suppression of lncRNA OIP5-AS1 Attenuates Apoptosis and Inflammation, and Promotes Proliferation by Mediating miR-25-3p Expression in Lipopolysaccharide-Induced Myocardial Injury 