Overexpression of Bruton Tyrosine Kinase Inhibits the Proliferation, Migration, and Invasion of Non-Small Cell Lung Cancer Cells

Table 1

Independent prognostic analysis of BTK and clinicopathological parameters.

Factor	Samples (N)	Single factor analysis		Multifactor analysis
		Hazard ratio (95% CI)	P value	Hazard ratio (95% CI)	P value
Gender	526
Female	280
Male	246	1.070 (0.803–1.426)	0.642
Age	516
≤65	255
>65	261	1.223 (0.916–1.635)	0.172
T	523
T1 and T2	457
T3 and T4	66	2.317 (1.591–3.375)	<0.001	1.818 (1.142–2.892)	0.012
N	510
N0	343
N1 and N2 and N3	167	2.601 (1.944–3.480)	<0.001	2.114 (1.440–3.103)	<0.001
M	377
M0	352
M1	25	2.136 (1.248–3.653)	0.006	1.370 (0.720–2.605)	0.338
Cancer stage	518
I and II stage	411
III and IV stage	107	2.664 (1.960–3.621)	<0.001	1.279 (0.785–2.081)	0.323
BTK	526
Low-level	262
High expression	264	0.539 (0.401–0.725)	<0.001	0.546 (0.383–0.779)	<0.001

Bold values signify the statistically significant ().