Mesenchymal Stem Cell-Derived Exosomal miRNA-222-3p Increases Th1/Th2 Ratio and Promotes Apoptosis of Acute Myeloid Leukemia Cells

Figure 4

IRF2 partially reverses the effect exerted by miR-222-3p on Th1/Th2 ratio and AML apoptosis. (a and b) The Th1/Th2 ratio and AML apoptosis were both detected by flow cytometry in the exosome + mimic NC + Over-NC group, the exosome + miR-222-3p mimic + over-NC group, the exosome + mimic NC + over-IRF2 group, the exosome + miR-222-3p mimic + over-IRF2 group, the exosome + inhibitor NC + Si-NC group, the exosome + miR-222-3p inhibitor + Si-NC group, the exosome + inhibitor NC + Si-IRF2 group, and the exosome + miR-222-3p inhibitor + Si-IRF2 group. (c) Western blot was used to detect the expression of caspase 3 in the above eight groups. β-actin acts as control. *, ****.

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