Research Article
TMEM147 Correlates with Immune Infiltration and Serve as a Potential Prognostic Biomarker in Hepatocellular Carcinoma
Table 1
Association of TMEM147 expression and clinicopathological features in HCC (
).
| | Characteristic | Level | Low expression of TMEM147 | High expression of TMEM147 | | Method |
| | N | | 187 | 187 | | | | T stage, n (%) | T1 | 108 (29.1%) | 75 (20.2%) | 0.005 | Chisq. test | | T2 | 41 (11.1%) | 54 (14.6%) | | | T3 | 30 (8.1%) | 50 (13.5%) | | | T4 | 6 (1.6%) | 7 (1.9%) | | | N stage, n (%) | N0 | 126 (48.8%) | 128 (49.6%) | 0.122 | Fisher test | | N1 | 0 (0%) | 4 (1.6%) | | | M stage, n (%) | M0 | 128 (47.1%) | 140 (51.5%) | 0.624 | Fisher test | | M1 | 1 (0.4%) | 3 (1.1%) | | | Pathologic stage, n (%) | Stage I | 103 (29.4%) | 70 (20%) | 0.004 | Fisher test | | Stage II | 38 (10.9%) | 49 (14%) | | | Stage III | 34 (9.7%) | 51 (14.6%) | | | Tumor status, n (%) | Tumor free | 110 (31%) | 92 (25.9%) | 0.163 | Chisq. test | | With tumor | 71 (20%) | 82 (23.1%) | | | Stage IV | 1 (0.3%) | 4 (1.1%) | | | Gender, n (%) | Female | 54 (14.4%) | 67 (17.9%) | 0.185 | Chisq. test | | Male | 133 (35.6%) | 120 (32.1%) | | | Race, n (%) | Asian | 72 (19.9%) | 88 (24.3%) | 0.278 | Chisq. test | | Black or African American | 9 (2.5%) | 8 (2.2%) | | | White | 99 (27.3%) | 86 (23.8%) | | | Age, n (%) | ≤60 | 83 (22.3%) | 94 (25.2%) | 0.323 | Chisq. test | | >60 | 103 (27.6%) | 93 (24.9%) | | | Weight, n (%) | ≤70 | 78 (22.5%) | 106 (30.6%) | 0.002 | Chisq. test | | >70 | 96 (27.7%) | 66 (19.1%) | | | BMI, n (%) | ≤25 | 77 (22.8%) | 100 (29.7%) | 0.019 | Chisq. test | | >25 | 91 (27%) | 69 (20.5%) | | | Histologic grade, n (%) | G1 | 35 (9.5%) | 20 (5.4%) | <0.001 | Chisq. test | | G2 | 102 (27.6%) | 76 (20.6%) | | | G3 | 43 (11.7%) | 81 (22%) | | | G4 | 5 (1.4%) | 7 (1.9%) | | | AFP (ng/ml), n (%) | ≤400 | 123 (43.9%) | 92 (32.9%) | <0.001 | Chisq. test | | >400 | 20 (7.1%) | 45 (16.1%) | | | Vascular invasion, n (%) | No | 118 (37.1%) | 90 (28.3%) | 0.007 | Chisq. test | | Yes | 44 (13.8%) | 66 (20.8%) | | | Fibrosis Ishak score, n (%) | 0 | 47 (21.9%) | 28 (13%) | 0.343 | Chisq. test | | 1/2 | 17 (7.9%) | 14 (6.5%) | | | 3/4 | 12 (5.6%) | 16 (7.4%) | | | 5/6 | 45 (20.9%) | 36 (16.7%) | | | Adjacent hepatic tissue inflammation, n (%) | None | 76 (32.1%) | 42 (17.7%) | 0.027 | Chisq. test | | Mild | 47 (19.8%) | 54 (22.8%) | | | Severe | 11 (4.6%) | 7 (3%) | | | OS event, n (%) | Alive | 137 (36.6%) | 107 (28.6%) | 0.002 | Chisq. test | | Dead | 50 (13.4%) | 80 (21.4%) | | | Age, median (IQR) | | 62 (54, 69) | 60 (50, 68) | 0.123 | Wilcoxon |
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BMI: body mass index; AFP: alpha-fetoprotein; OS: overall survival; IQR: inter-quartile range.
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