TMEM147 Correlates with Immune Infiltration and Serve as a Potential Prognostic Biomarker in Hepatocellular Carcinoma

Table 3

A multivariate and univariate Cox proportional hazards analysis of TMEM147 expression in HCC.

Characteristics	Total (N)	Univariate analysis		Multivariate analysis
		Hazard ratio (95% CI)	value	Hazard ratio (95% CI)	value
T stage (T2 & T3 & T4 vs. T1)	370	2.126 (1.481–3.052)	<0.001	1.433 (0.798–2.574)	0.228
N stage (N0 vs. N1)	258	2.029 (0.497–8.281)	0.324
M stage (M1 vs. M0)	272	4.077 (1.281–12.973)	0.017	1.208 (0.287–5.079)	0.797
Pathologic stage (Stage I & Stage II vs. Stage III & Stage IV)	349	2.504 (1.727–3.631)	<0.001	1.944 (1.128–3.351)	0.017
Tumor status (tumor free vs. with tumor)	354	2.317 (1.590–3.376)	<0.001	1.977 (1.239–3.155)	0.004
Gender (female vs. male)	373	0.793 (0.557–1.130)	0.2
Race (White vs. Black or African American)	361	0.791 (0.551–1.135)	0.203
Age (≤0 vs. >60)	373	1.205 (0.850–1.708)	0.295
Weight (≤70 vs. >70)	345	0.941 (0.657–1.346)	0.738
BMI (≤25 vs. >25)	336	0.798 (0.550–1.158)	0.235
Histologic grade (G1 & G2 vs.G3 & G4)	368	1.091 (0.761–1.564)	0.636
AFP (ng/ml) (≤400 vs. >400)	279	1.075 (0.658–1.759)	0.772
Vascular invasion (no vs. yes)	317	1.344 (0.887–2.035)	0.163
Fibrosis Ishak score (0 & 1/2 vs. 3/4 & 5/6)	214	0.740 (0.445–1.232)	0.247
Adjacent hepatic tissue inflammation (none vs. mild & severe)	236	1.194 (0.734–1.942)	0.475
TMEM147 (low vs. high)	373	2.079 (1.458–2.966)	<0.001	2.121 (1.336–3.369)	0.001

TMEM147: transmembrane protein 14.