Selenium Donor Inhibited Hepatitis B Virus Associated Hepatotoxicity via the Apoptosis and Ferroptosis Pathways

Figure 4

Effects of Na₂SeO₃ on HBx-related ferroptosis. (a–c) HL7702 cells were transduced with leti-HBx or leti-NC as empty control for 24 hr, and then were treated with 50 mM D-GalN, along with Na₂SeO₃ at 500 nM for 6 hr, and then the cells were harvested and the (a) GPx activities; (b) MDA levels; and (c) relative iron levels were determined. (d, e) HL7702 cells were transduced with leti-HBx or leti-NC as empty control for 24 hr, and then were treated with Erastin at 10 μM, along with Na₂SeO₃ at 500 nM for 6 hr, and then the cells were harvested and the (d) GPx activities; (e) MDA levels; and (f) relative iron levels were determined. ; ; .

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