Selenium Donor Inhibited Hepatitis B Virus Associated Hepatotoxicity via the Apoptosis and Ferroptosis Pathways

<div>Similar function of Fer-1 and Na<sub>2</sub>SeO<sub>3</sub> on the HBx-related hepatotoxicity. (a) HL7702 cells were transduced with leti-HBx or leti-NC as empty control for 24 hr, and then were treated with 50 mM D-GalN, along with Na<sub>2</sub>SeO<sub>3</sub> at 500 nM or Fer-1 at 1 <i>μ</i>M for 6 hr, and then the cell viability was monitored by MTT assay. (b) HL7702 cells were transduced with leti-HBx or leti-NC as empty control for 24 hr, and then were treated with Erastin at 10 <i>μ</i>M, along with Na<sub>2</sub>SeO<sub>3</sub> at 500 nM or Fer-1 at 1 <i>μ</i>M for 6 hr, and then the cell viability was monitored by MTT assay. <span class="nowrap"><svg height="10.7395pt" id="M18" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -10.1025 53.0975 10.7395" width="53.0975pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,2.179,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 145 220C133 201 125 177 126 158C141 148 167 143 189 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Analytical Cellular Pathology

fig5

Figure 5

Figure 5: Selenium Donor Inhibited Hepatitis B Virus Associated Hepatotoxicity via the Apoptosis and Ferroptosis Pathways 