Selenium Donor Inhibited Hepatitis B Virus Associated Hepatotoxicity via the Apoptosis and Ferroptosis Pathways

Figure 7

Treatment with Na₂SeO₃ or Fer-1 mitigated LPS/D-GalN-induced hepatic injury in vivo. The WT and HBx-Tg mice were subjected to control or LPS (0.25 mg/Kg) and D-GaIN (400 mg/Kg) treatment for 5 hr, as well as Na₂SeO₃ (3 mg/kg) or Fer-1 (10 mg/kg) administration. (a and b) Serum (a) ALT and (b) AST activities of each group. (c) Liver histopathology of each group. (d and e) Ferroptosis markers, including (d) MDA levels and (e) relative iron levels of each group. Each treatment group was composed of eight mice, which were kept in a cage. ; ; .

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