Diagnostic Accuracy of p16^INK4a/Ki-67 Dual Immunostaining for Detection of High-Grade Cervical Intraepithelial Neoplasia in Women Involved in Cervical Cancer Screening in Georgia

Table 10

Sensitivity, specificity, PPV, and NPV of p16^INK4a/Ki-67 DS for detection of CIN2+ in various study.

Study	Test on cervical smear for detection CIN2+ lesions	Sensitivity (%) (95% CI)	Specificity (%) (95% CI)	PPV (%)	NPV (%)
Gajsek et al. [30]	p16^INK4a/Ki-67 DS	88.1	65.2	44.6	94.5
Ikenberg et al. [31]		86.7	95.2	15.6	99.9
Luttmer et al. [32]		93.8	51.2	29.9%	2.6
Nkwabong et al. [38]	Pap test	55.5	75	88.2	33.3
Ikenberg et al. [31]		68.5	95.4	13.3	99.7