A-Kinase Anchor Protein 95 Is Involved in ERK1/2–Elk-1 Signal Transduction in Colon Cancer

Figure 1

Representative images showing AKAP95, B-Raf, ERK1/2, and ELK-1 expressions in colon cancer and para-carcinoma tissue (magnification = 10×). (a1) No AKAP95 expression in para-carcinoma tissue. (b1) AKAP95 showing some expression (− or ±) in colon cancer tissue. (c1) Lowly expressed AKAP95 (+) in colon cancer tissue. (d1) Moderately expressed AKAP95 (++) in colon cancer tissue. (e1) Highly expressed AKAP95 (+++) in colon cancer tissue. (d1) and (e1) AKAP95 expression not only in the nuclei, but also in the cytoplasm. (a2) No B-Raf expression in para-carcinoma tissue. (b2) B-Raf showing some expression (− or ±) in colon cancer tissue. (c2) Lowly expressed B-Raf (+) in colon cancer tissue. (d2) Moderately expressed B-Raf (++) in colon cancer tissue. (e2) Highly expressed B-Raf (+++) in colon cancer tissue. (c2)–(e2) B-Raf expression in the cytoplasm. (a3) No ERK1/2 expression in para-carcinoma tissue. (b3) ERK1/2 showing some expression (− or ±) in colon cancer tissue. (c3) Lowly expressed ERK1/2 (+) in colon cancer tissue. (d3) Moderately expressed ERK1/2 (++) in colon cancer tissue. (e3) Highly expressed ERK1/2 (+++) in colon cancer tissue. (c3) ERK1/2 mainly expression in the cytoplasm. (d3) and (e3) ERK1/2 expression in the cytoplasm and nucleus. (a4) No ELK-1 expression in para-carcinoma tissue. (b4) ELK-1 showing some expression (− or ±) in colon cancer tissue. (c4) Lowly expressed ELK-1 (+) in colon cancer tissue. (d4) Moderately expressed ELK-1 (++) in colon cancer tissue. (e4) Highly expressed ELK-1 (+++) in colon cancer tissue. (c4) and (d4) ELK mainly expression in the cytoplasm. (e4) ELK-1 expression in the cytoplasm and nucleus.