METTL16 Inhibits the Malignant Progression of Epithelial Ovarian Cancer through the lncRNA MALAT1/β-Catenin Axis

Figure 1

METTL16 is lowly expressed in EOC. (a, b) Volcano plot (a) and clustered heatmap (b) analyses of GSE190688 dataset revealed that METTL16 was differentially expressed in EOC. (c) The mRNA expression of METTL16 in normal ovary tissues (n = 88) and OC tissues (n = 426) in the TCGA database. (d) The overall survival (OS) EOC patients in the Kaplan–Meier plotter database with a low- or high-expression level of METTL16 were examined using the KM plotter online tool (http://www.kmplot.com). (e) The mRNA expression of METTL16 was detected by RT-qPCR in adjacent noncancerous tissues (n = 30) and EOC tissues (n = 30) of our own cohorts. (f) The H-score of METTL16 in adjacent noncancerous tissues (n = 30) and EOC tissues (n = 30) of our own cohorts. (g) The protein expression of METTL16 detected by IHC in adjacent noncancerous tissues (n = 30) and EOC tissues (n = 30) of our own cohorts (scale bar, 20 μm). , , and . None: genes of no interest, P-m6A: m6A genes, P-up: upregulated genes, P-down: downregulated genes.

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