Research Article
Astragaloside IV Protects against Shear Stress-Induced Glycocalyx Damage and Alleviates Abdominal Aortic Aneurysm by Regulating miR-17-3p/Syndecan-1
Figure 4
miR-17-3p inhibits SDC1 expression in HAECs. (a) The targeted binding sites of miR-17-3p and SDC1 mRNA. (b) The relationship between miR-17-3p and SDC1 was confirmed using the dual-luciferase report assay. (c) miR-17-3p overexpression by transfection. (d, e) Comparison of SDC1 mRNA and protein levels in HAECs in each group. (f) miR-17-3p silencing by transfection. (g, h) Comparison of SDC1 mRNA and protein levels in HAECs in each group. vs. Mut-SDC1 group or Control group; ### vs. miR-17-3p NC group. SDC1, syndecan-1 and HAECs, human aortic endothelial cells.
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