Regulation of Cancer-Associated miRNAs Expression under Hypoxic Conditions

Table 1

Up miRNAs expression under hypoxic environment.

miRNA	Cells/tissue	Cancer type	Target	Hallmark	References
miR-9	U87	Glioblastoma	HIF-1α	Proliferation, invasion	[32]
miR-10b-3p	ECA109	Esophageal	TSGA10	Growth, metastasis	[33]
miR-17-92	BEAS2B, HPL1D	Lung	HIF-1α	Proliferation	[34]
miR-18a	MDA-MB-231, MCF7	Breast	HIF-1α	Metastasis	[35]
miR-20b	H22, 4T1, RM1, B16	Hepatocellular, breast, prostate, melanoma	HIF-1α, VEGF	Survival	[36]
miR-21	AsPC-1, BxPC-3	Pancreatic	HIF-1α, VEGF, IL6	Apoptosis, migration, invasion	[37]
miR-27a	OCUM-2MD3, A2780, HO8910, OVCAR3	Gastric, ovarian	MDR	Apoptosis, drug resistance, angiogenesis	[38, 39]
miR-30b-5p	PDAC	Pancreatic	GJA1	Angiogenesis	[40]
miR-96	LNCaP, 22Rv1	Prostate	mTOR, ATG7	Autophagy	[41]
miR-98	SCC-4, SCC-9	Head/neck	HMGA2	Proliferation	[42]
miR-101	ACHN, HK-2, tissue	Kidney	TIGAR	Glycolysis	[43]
miR-135b	RPMI8226, KMS-11, U266	Myeloma	HIF-1α	Angiogenesis	[44]
miR-146a	Blood	Leukemia	CXCR4	Survival	[45]
miR-147a	HeLa	Cervical	HIF-1α	Proliferation	[46]
miR-155	A549, Caki1, KTCTL-26, HeLa	Lung, kidney, cervical	FOXO3, mTOR, RICTOR	Radiosensitivity, autophagy	[47–49]
miR-181a	JJ, tissue	Chondrosarcoma	CXCR4, RGS16	Angiogenesis, metastasis	[50]
miR-181b	HXO-RB44	Retinoblastoma	PDCD10, GATA6	Angiogenesis	[51]
miR-182	SK-HEP-1 (PC)-3, DU-145	Liver, prostate	RASA1, PHD2, FIH1	Angiogenesis, progression	[52, 53]
miR-184	U251, TJ899, A172	Glioblastoma	HIF-1α, FIH-1	Invasion, apoptosis	[54]
miR-191	MCF7, MM231	Breast	HIF-1α, TGFβ	Migration	[55]
miR-196a	U87MG, A172	Glioblastoma	NRAS	Proliferation, migration	[56]
miR-199a-5p	Tissue	Sarcoma	HIF-1α, OSGIN2	Worse prognosis	[57]
miR-210	SU86.86, PANC1, A549, HT-29, SW480, SW620, KMS-5, KMS-11, tissue	Pancreatic, lung, colon, myeloma	HOXA1, FGFRL1, HIF-1α, VMP1, SDHD, DIMT1, IRF4, CAIX, NF-κB	Proliferation, survival, invasion, metastasis, drug resistance, EMT	[58–61]
miR-215	D456MG, tissue	Glioblastoma	KDM1B	Epigenetic regulation	[62]
miR-224	SGC-7901, MGC-803, tissue	Gastric	HIF-1α, RASSF8	Proliferation, migration, invasion	[63]
miR-301a	Panc-1, BxPC-3, CFPAC-1	Pancreatic	TP63	EMT	[64]
miR-301a-3p	MGC803, MKN45	Gastric	PHD3, HIF-1α	Progression, metastasis	[65]
miR-301b-3p	DU145, PC-3, LNCaP	Prostate	LRP1B	Migration, invasion	[66]
miR-340-5p	Te13, Te1, Eca109	Esophageal	KLF10, UVRAG	Apoptosis, radioresistance	[67]
miR-346	OS-RC-2, 786-O	Kidney	NDRG2	Proliferation, migration, invasion	[68]
miR-421	AGS, SGC-7901	Gastric	E-cadherin, Caspase-3	Apoptosis, metastasis	[69]
miR-485-5p	T98G, LN229, U251-MG	Glioblastoma	SRPK1	Aggressiveness	[70]
miR-488	HOS, tissue	Osteosarcoma	Bim	Apoptosis	[71]
miR-497	U87, U25	Glioblastoma	PDCD4	Apoptosis	[72]
miR-630	A2780, OVCAR	Ovarian	Dicer	Progression	[73]
miR-675-5p	SW620, HCT116	Colon	GSK-3β, Caspase-3	Invasion, drug resistance	[74]
miR-1908	LNCaP, 22Rv1	Lung	Akt, p53	Proliferation	[75]
miR-1273f	Huh7, MHCC-97H	Liver	LHX6	Proliferation, metastasis	[76]

Abbreviations. HIF-1α, hypoxia-inducible factor 1 alpha; TSGA10, pancreatic ductal adenocarcinoma (PDAC), testis specific 10; VEGF, vascular endothelial growth factor; IL-6, interleukin 6; MDR, multidrug resistance protein; GJA1, gap junction protein alpha 1; mTOR, target of rapamycin in mammalian cells; ATG7, autophagy type 7 protein; HMGA2, high-mobility group AT-Hook 2; TIGAR, PT53-induced regulator of glycolysis and apoptosis; CXCR4, CXC-type chemokine receptor 4; FOXO3, forkhead box O3; RICTOR, rapamycin-insensitive chaperone of mTOR; RGS16, regulator of G-protein signaling 16; PDCD4 or 10, programed cell death proteins 4 or 10; GATA-6, GATA-6-binding factor; RASA1, RAS activator protein P21 type 1; PDH2, HIF-prolyl hydroxylase isoforms 2; FIH-1, HIF-1α-inhibitory factor; TGFβ, transforming growth factor beta 1; NRAS, neuroblastoma proto-oncogene GTPase; OSGIN2, oxidative stress-induced growth inhibitor type 2; HOXA1, homeobox A1; FGFRL1, fibroblast growth factor receptor 1; VMP1, vacuole membrane protein 1; SDHD, subunit D of succinate dehydrogenase complex; DIMT1, dimethyltransferase type 1; IRF4, interferon regulatory factor 4; CAIX, carbonic anhydrase IX; NF-κB, nuclear factor-kappa B; EMT, epithelial–mesenchymal transition; KDM1B, lysine demethylase 1B; RASSF8, ras-associated domain member 8; TP63, tumor protein P63; PDH3, HIF-prolyl hydroxylase isoforms 3; LRP1B, LDL receptor related protein 1B; KLF10, kruppel-like factor 10; UVRAG, UV radiation resistance associated; NDRG2, N-myc downstream-regulated gene 2; SRPK1, SRSF protein kinase 1; GSK-3β, glycogen synthase kinase 3β; Akt, protein kinase B; LHX6, LIM homeobox domain 6.