Regulation of Cancer-Associated miRNAs Expression under Hypoxic Conditions

Table 2

Down miRNAs expression in a hypoxic environment.

miRNA	Cells/tissue	Cancer type	Target	Hallmark	References
miR-17/20a	AML	Leukemia	STAT3	Cell differentiation	[77]
miR-18a	MGC-803, HGC-27	Gastric	BCL-2, BAX	Invasion, apoptosis	[78]
miR-20b	MG63, U2OS, tissue	Osteosarcoma	VEGF	Proliferation, invasion	[36]
miR-22	HCT116, tissue	Colon	VEGF	Angiogenesis	[79]
miR-30c	ACHN, Caki-1, 786-O, tissue	Kidney	E-cadherin	EMT	[80]
miR-100	RT4, RT112, T24	Bladder	HIF-1α, FGFR3	Survival	[81]
miR-124	DU145, PC3, U87MG, U373	Prostate, glioblastoma	PIM1, TEAD1, SERP1	Autophagy, radiosensitivity	[82]
miR-130a	A549	Lung	HIF-1α	Migration, invasion	[83]
miR-138-5p	AsPC-1, BxPC-3, PANC-1	Pancreatic	SIRT1	Autophagy	[84]
miR-140-5p	MCF-7, MDA-MB-231	Breast	Nrf2, HO-1	Angiogenesis, migration	[85]
miR-141-3p	MCF-7, MDA-MB-231	Breast	HMGB1	Migration	[86]
miR-142	PANC-1, SW1990	Pancreatic	E-cadherin, vimentin	Proliferation, invasion	[87]
miR-144	DU145, PC3	Prostate	PIM1	Autophagy, radiosensitivity	[82]
miR-150	CaPan2, tissue	Pancreatic	CXCR4	Migration, invasion	[88]
miR-186	MKN45, SGC7901	Gastric	Glucose, lactate	Glycolysis	[89]
miR-196b	HepG2	Liver	IGF2BP1	Proliferation, apoptosis	[28]
miR-199a	MG-63, U-2OS, SaoS-2	Osteosarcoma	HIF-1α	Drug resistance	[90]
miR-199a-3p	MCF-10A, MDA-MB-468, MCF-7	Breast	HIF-1α, SNHG1, TFAM	Angiogenesis, metastasis	[91]
miR-199a-5p	OPM2, U266, KMS11, MM1S	Myeloma	VEGF-A, IL-8, FGFβ	Angiogenesis	[57]
miR-200c	A549, NCI-H460	Lung	HIF-1α	Migration	[92]
miR-210	Tissue	Liver	TIMP2	Metastasis	[93]
miR-211	A375, WM1552C	Melanoma	PDK4	Energetic metabolism	[94]
miR-218	ACHN, 769-p, Caki-1	Kidney	CXCR7	Apoptosis, invasion	[95]
miR-224-3p	U251, U87, tissue	Glioblastoma	ATG5	Autophagy	[96]
miR-338-3p	HepG2, Huh-7, BEK-7402, Hep3B	Liver, gastric	HIF-1α, SOX5, β-Catenin	Apoptosis, worse prognosis	[97, 98]
miR-338-5p	HCT116, HCT8	Colon	HIF-1α, IL-6	Drug resistance	[99]
miR-374b	PC-3	Prostate	HIF-1α, VEGF	Angiogenesis	[100]
miR-375	Neuro-2a	Neuroblastoma	DBH, PNMT	Hypertension	[101]
miR-433-3p	CNE2	Nasopharyngeal	SCD1	Proliferation, migration, lipid synthesis	[102]
miR-494	MB-231 (MB)-468	Breast	HIF-1α	Drug resistance	[103]
miR-495	A549, H1299	Lung	IL-11	Proliferation, migration, invasion	[104]
miR-497-5p	AGS, HGC-27	Gastric	EGFR	Migration, invasion, EMT	[105]
miR-576-3p	U87, U251, T98, LN229, U118	Glioblastoma	HIF-1α	Migration, angiogenesis	[106]
miR-615-3p	A549, H1299	Lung	HMGB3	Glycolysis	[107]
miR-758-3p	ECA-109, EC9706, KYSE150	Esophageal	WTAP	Drug resistance	[108]
miR-3195	PC-3	Prostate	HIF-1α, VEGF	Angiogenesis	[100]
miR-4521	BGC823, SGC7901, MGC803	Gastric	IGF2, FOXM1	Invasion, metastasis	[109]

Abbreviations. STAT3, signal transducer and activator of transcription 3; BCL2 and BAX apoptosis regulators; VEGF, vascular endothelial growth factor; EMT, epithelial–mesenchymal transition; HIF-1α, hypoxia-inducible factor 1 alpha; FGFR3, fibroblast growth factor receptor 3; PIM1, proto-oncogene serine/threonine kinase; TEAD1, transcriptional enhancer factor TEF-1; SERP1, stress-associated endoplasmic reticulum protein 1; SIRT1, sirtuin-1 NAD-dependent deacetylase; Nrf2, factor erythroid 2-related factor 2; HO-1, heme oxygenase-1; HMGB1, high-mobility group box protein 1; CXCR4 and 7, CXC chemokine receptors 4 and 7; IGF2BP1, insulin-like growth factor 2 mRNA-binding protein; SNHG1, small nucleolar RNA host gene 1; TFAM, mitochondrial transcription factor A; IL-6, 8 and 11, interleukin 6, 8 and 11; FGFβ, basic fibroblast growth factor β; TIMP2, tissue inhibitor of metalloproteinase 2; PDK4, pyruvate dehydrogenase kinase 4; ATG5, autophagy protein type 5; SOX5, SRY-box transcription factor 5; DBH, dopamine β-hydroxylase; PNMT, phenylethanolamine N-methyltransferase; SCD1, stearoyl-CoA desaturase 1; EGFR, epidermal growth factor receptor; HMGB3, high-mobility group box 3; WTAP, WT1-associated protein; IGF2, insulin like growth factor 2; FOXM1, forkhead box M1.