The Clinical and Pathological Effects of Serum C3 Level and Mesangial C3 Intensity in Patients with IgA Nephropathy

Table 5

C3 deposition in mesangial area and laboratory examination indexes.

Laboratory examination	Negative	Weakly positive	Strongly positive	P Value
FPG (mmol/L)	5.32 ± 1.02	5.03 ± 0.84	5.16 ± 0.55	0.107
BUN (mmol/L)	5.56 ± 2.15	6.04 ± 2.69	7.4 ± 3.04	0.003
UA (umol/L)	363.63 ± 104.07	382.87 ± 129.73	435.65 ± 125.5	0.016
Scr (umol/L)	79.89 ± 30.7	91.27 ± 37.21	114.1 ± 48.63	0.001
eGFR (mL/min/1.73 m^2)	105.91 ± 43.39	94.79 ± 43.14	75.32 ± 38.85	0.003
Alb (g/L)	36.14 ± 9.83	36.56 ± 8.04	38.1 ± 7.04	0.552
TC (mmol/L)	6.27 ± 2.61	6.11 ± 2.48	6.06 ± 1.69	0.900
LDL-C (mmol/L)	4.01 ± 2.31	3.85 ± 1.86	3.83 ± 1.32	0.873
HDL (mmol/L)	1.2 ± 0.35	1.32 ± 0.48	1.27 ± 0.44	0.280
TG (mmol/L)	2.31 ± 1.33	1.87 ± 1.01	2.57 ± 2.31	0.098
Serum IgA (mg/L)	336.32 ± 167.42	334 ± 126.01	352.94 ± 115.4	0.813
Serum IgG (mg/L)	1055.91 ± 409.46	933.16 ± 337.26	950.94 ± 412.63	0.192
Serum IgM (mg/L)	114.93 ± 51.41	113.1 ± 58.61	104.45 ± 42.23	0.619
Serum C3 (mg/dL)	120.66 ± 24.9	105.23 ± 25.33	91.43 ± 27.32	0.001
24hUP (g/24 hr)	3.73 ± 3.32	3.65 ± 2.83	3.08 ± 2.34	0.558
IgA/C3 ratio	2.91 ± 1.67	3.34 ± 1.41	4.31 ± 2.42	0.001

Abbreviations. FPG, fasting plasma glucose; BUN, blood urea nitrogen; UA, uric acid level; Scr, serum creatinine; Alb, albumin; TC, total cholesterol; LDL-C, low-density lipoprotein cholesterin; HDL, high-density lipoprotein cholesterin; TG, triglyceride; 24hUP, 24-hr urinary total protein, 24hUP.