Heat Shock Proteins: Pathogenic Role in Atherosclerosis and Potential Therapeutic Implications

Table 1

Functions of heat shock proteins.

Heat shock protein molecular weight (kilodaltons)	Function	Pathologic associations
60	Protein folding	Atherosclerosis
	Protein unfolding	Rheumatoid arthritis
	Polypeptide assembly	Systemic sclerosis
	Protein translocation across membranes	Schizophrenia
		Diabetes mellitus
10	Cofactor for HSP 60	Cardiovascular disease
27	Competes for uptake with lipids	Atherosclerosis
	Estrogen receptor-𝛽-associated protein
70	Protein folding	Atherosclerosis
	Protein unfolding	Leprosy
	Degradation of misfolded or denatured proteins	Tuberculosis
	Assembly of new proteins
	Translocation of proteins across membranes
90	Molecular chaperone involved in protein folding and activation	Atherosclerosis
		Systemic lupus erythematosus