The Role of Simvastatin in the Therapeutic Approach of Rheumatoid Arthritis

Table 2

Differences after 3 and 6 months of treatment.

Variable	Follow-up visit	Simvastatin group	Control group	𝑃
Early morning stiffness (min)	3 month	0.244(−5.346;5.834)	−1.125(−9.962;7.712)	0.63
	6 month	−3.536(−7.701;0.628)	−2.25(−10.804;6.304)	0.996
Tender joint count	3 month	−3(−4.894;−1.106)	−0.225(−2.591;2.141)	0.03
	6 month	−1.414(−3.513;0.684)	1.650(−1.009;4.309)	0.243
Swollen joint count	3 month	−0.561(−1.143;0.021)	0.275(−0.431;0.981)	0.068
	6 month	−0.341(−0.808;0.125)	0.050(−0.425;0.525)	0.288
VAS pain (mm)	3 month	−1.219(−8.762;6.323)	3.75(−4.561;12.061)	0.888
	6 month	−1.219(−7.421;4.982)	4.500(−4.745;13.745)	0.481
Patient global assessment (mm)	3 month	−4.39(−10.255;1.475)	0.25  (−6.084;6.584)	0.273
	6 month	−2.926  (−8.714;2.861)	−5.00  (−13.900;3.900)	0.196
Evaluator global assessment (mm)	3 month	−7.561  (−10.620;−4.502)	3  (−0.255;6.255)	<0.001
	6 month	−8.049  (−12.412;−3.685)	1.500  (−3.279;6.279)	0.007
HAQ-DI	3 month	−0.064(−0.172;0.043)	−0.122(−0.288;0.043)	0.353
	6 month	−0.153(−0.283;−0.023)	−0.019(−0.194;0.154)	0.149
Erythrocyte sedimentation rate (mm/h)	3 month	−0.926(−4.653;2.799)	2.125(−2.712;6.962)	0.203
	6 month	2.829(−1.046;6.705)	3.800(−1.018;8.618)	0.751
C-reactive protein (mg/L)	3 month	0.961(−0.178;−2.101)	3.767(1.506;−6.027)	0.055
	6 month	1.676(−0.833;4.186)	2.57(0.641;4.499)	0.687
DAS28 ESR	3 month	−0.56(−0.849;−0.270)	0.076(−0.312;0.465)	0.009
	6 month	−0.313(−0.641;0.013)	0.073(−0.391;0.537)	0.171
DAS28 CRP	3 month	−0.484(−0.771;−0.196)	0.090(−0.309;0.491)	0.02
	6 month	−0.295(−0.637;0.045)	0.098(−0.334;0.531)	0.151
SDAI	3 month	−4.708(−6.889;−2.527)	0.951  (−2.061;3.963)	0.003
	6 month	−2.466  (−5.257;0.324)	1.807  (−1.939;5.553)	0.067
CDAI	3 month	−4.805  (−6.972;−2.637)	0.575  (−2.397;3.547)	0.004
	6 month	−2.634(−5.355;0.086)	1.55(−2.139;5.239)	0.068
EULAR response	3 month	16 (32%)	7 (14%)	0.033
	6 month	15 (30%)	11 (22%)	0.364
Attendance to visit	3 month	48 (96%)	49 (98%)	0.560
	6 month	45 (90%)	43 (86%)	0.540

Between the breaks, there are 95% confidence interval or percents.