A Tandem Repeat in Decay Accelerating Factor 1 Is Associated with Severity of Murine Mercury-Induced Autoimmunity
Figure 2
Daf1 gene organization showing location of the CTTTTn tandem repeat. Diagrammatic representation of exons (E) in Daf1 (top) and the expanded region of sequence in intron 2 (bottom) showing the CTTTT tandem repeat (shaded box) and PCR primers sequences (underlined). DNA sequence is from the C57BL/6 genomic sequence which has ten CTTTT repeats. Note that the repeat can also be represented by TTTTC by simple removal of the C residue at the 5′ end and inclusion of the C at the 3′ end. DBA/2 mice had the longest repeat sequence with CTTTT (or TTTTC) being repeated 11 times. NZB, NZW, BXSB, B10.S, C57BL/6, A.SW/Sn, BALB/c, and 129S6 mice had 10 repeats while MRL- and SJL/J lacked the repeat.
