Neuroantibody Biomarkers: Links and Challenges in Environmental Neurodegeneration and Autoimmunity
Figure 2
Serum titers of IgG against neurotypic (NF) and gliotypic (GFAP and MBP) proteins in hens () administered a single dose of OPIDP-inducing phenyl saligenin phosphate (2.5 mg/kg, im). Serum was collected at 7, 14, and 21 days. Mean levels of IgG (±S.E.) were significantly (∗) higher at 14 and 21 days compared to 7 days. With the exception of anti-NF-L and anti-MBP titers, there were no statistical differences between 14 and 21 days, suggesting peaking of the anti-NF-M, anti-NF-H, and anti-GFAP titers against these antigens. There was no detectable titer of antibodies against these antigens in control hens or in sera of hens prior to PSP administration.
