Neuroantibody Biomarkers: Links and Challenges in Environmental Neurodegeneration and Autoimmunity

Table 2

Protein antigens, their cellular source, and function.

Cell	Protein	Function
Neuron	Neurofilament (NF) Triplet*	Neuronal intermediate filaments (IF)
	NF-L (light; NF-68)	Mechanical stability of soma, dendrites, and axon
	NF-M (medium; NF-160)	Mechanical stability of soma, dendrites, and axon
	NF-H (heavy; NF-200)	Together with NF-L and NF-M, mechanical stability of the axon
Astrocyte	Glial fibrillary acidic protein (GFAP)	IF of mature astrocytes; biomarker of reactive gliosis
	Vimentin	IF transiently expressed during development
Myelinating cells	Myelin basic protein (MBP)	Compaction protein of myelin in CNS and PNS
Oligodendroglia	Myelin oligodendrocyte protein (MOG)	CNS myelin
Schwann Cell	Peripheral myelin protein-22 (PMP-22)	PNS myelin

∗Individual proteins differ in their immunogenicity.