Autoimmune Mechanisms of Interferon Hypersensitivity and Neurodegenerative Diseases: Down Syndrome

Table 1

Candidate down syndrome neuropathology genes on Ch21.

Gene	Function
RCAN1	Regulator of calcineurin 1
MAFD3	Major affective disorder 3
JAM4	Junctional adhesion molecule 4
ADARB1	Adenosine deaminase, RNA specific, B1
DOPEY2	Dopey family member 2
mir155	micro-RNA 155
NCAM	Nuclear receptor interacting protein
DYRK	Dual specificity tyrosine-(y)-phosphorylation regulated kinase 1A
MX1	Myxovirus (influenza) resistance-1
SIM2	Single-minded homolog2 (drosophila)
SYNJ1	Synaptojanin 1
DIP2a	Disco interacting protein
PCP4	Purkinje cell protein 4
CD18	Integrein beta 2
SOD1 and SOD2	Superoxide dismutase