Alterations in cirRNA Expression Profile during the Development of Acute-on-Chronic Liver Failure Induced by Hepatitis B

Table 1

Differentially expressed circRNAs (ACLF vs. HC).

circRNA	CHB vs. HC		ACLF vs. HC		Regulation	Chromosome	Length	Strand	Type
	FC2	P_val	FC2	P_val
circRNA_00389	1.6887	0.1679	3.5835	0.0006	Down	chr1	363	+	Sense-overlapping
circRNA_02808	1.6185	0.4137	3.6685	0.0080	Down	chr10	361	—	Sense-overlapping
circRNA_03646	1.3686	0.4386	5.8769	0.0003	Down	chr11	6085	—	Intergenic
circRNA_04205	1.5300	0.2323	3.2813	0.0112	Down	chr12	1368	—	Sense-overlapping
circRNA_05781	1.7071	0.1450	3.2003	0.0131	Down	chr14	3199	—	Intergenic
circRNA_06400	1.5643	0.1009	3.3205	<0.0001	Down	chr14	369	—	Exonic
circRNA_07485	1.9656	0.1531	3.2457	0.0107	Down	chr16	845	+	Exonic
circRNA_07734	1.7126	0.1422	2.8129	0.0077	Down	chr16	313	+	Sense-overlapping
circRNA_08533	2.7321	0.0232	13.2602	<0.0001	Down	chr17	939	+	Sense-overlapping
circRNA_09331	1.4930	0.2115	7.4732	0.0004	Down	chr18	658	+	Exonic
circRNA_17523	1.5966	0.1871	3.7990	0.0074	Down	chr6	640	—	Sense-overlapping
circRNA_17526	2.4262	0.0631	6.1841	0.0091	Down	chr6	439	—	Sense-overlapping
circRNA_19214	1.8125	0.1170	7.6139	0.0001	Down	chr8	258	—	Sense-overlapping
circRNA_04487	0.5663	0.2698	4.4060	0.0010	Up	chr12	455	+	Sense-overlapping
circRNA_15699	0.6673	0.3637	3.6601	0.0351	Up	chr5	1923	+	Exonic
circRNA_16083	0.7123	0.5781	5.4313	<0.0001	Up	chr5	5262	+	Exonic
circRNA_16987	0.8639	0.8767	7.9830	<0.0001	Up	chr6	527	—	Sense-overlapping

Note: FC: fold change, absolute ratio (nonlog scale) of normalized intensities between two groups (threshold, 2.0); circRNA: circular RNA; hsa: Homo sapiens; +: positive strand; -: negative strand.