Alterations in cirRNA Expression Profile during the Development of Acute-on-Chronic Liver Failure Induced by Hepatitis B

Table 2

KEGG analysis of ACLF risk status in up- and downregulated circRNAs ranked by value and enrichment score.

circRNA	Path id	(10^-3)	Core	Term
Downregulated circRNAs
circRNA_00389	hsa05340	0.0424	91.525	Primary immunodeficiency
circRNA_00389	hsa05166	0.0177	11.5368	HTLV-I infection
circRNA_07734	hsa05150	0.1249	53.8382	Staphylococcus aureus infection
circRNA_00389	hsa04650	0.1724	14.0808	Natural killer cell-mediated cytotoxicity
circRNA_07734	hsa05144	0.2829	35.8922	Malaria
circRNA_07734	hsa05323	0.3921	30.5083	Rheumatoid arthritis
circRNA_08533	hsa05219	0.3921	30.5083	Bladder cancer
circRNA_07734	hsa05416	0.9218	19.8967	Viral myocarditis
circRNA_08533	hsa05230	1.5902	15.1281	Central carbon metabolism in cancer
circRNA_07734	hsa04514	1.7781	14.3008	Cell adhesion molecules (CAMs)
Up-regulated circRNAs
circRNA_15699	hsa04621	0.4187	29.5242	NOD-like receptor signaling pathway
circRNA_16083	hsa04514	1.7781	14.3008	Cell adhesion molecules (CAMs)
circRNA_16987	hsa04915	3.1911	10.6424	Estrogen signaling pathway
circRNA_04487	hsa04722	8.5407	6.4454	Neurotrophin signaling pathway