The Prognostic Value of Preoperative Fibrinogen in Patients with Radical Cholecystectomy

Table 2

Univariate and multivariate analyses of DFS in patients with GBC.

Factors	Univariate analysis			Multivariate analysis
	value	HR	95% CI	value	HR	95% CI
Gender (male vs. female)	0.873	1.030	0.716-1.481
Age (≤60 vs. >60)	0.172	0.7780	0.543-1.115
BMI (≤22.62 vs. >22.62)	0.550	1.018	0.960-1.079
Smoking history (no vs. yes)	0.823	1.049	0.688-1.602
Drinking history (no vs. yes)	0.599	1.128	0.720-1.770
Tumor location (body + fundus vs. neck)	0.023	1.619	1.067-2.456	0.353	1.241	0.787-1.957
Tumor size (≤3.5 cm vs. >3.5 cm)	0.127	1.068	0.918-1.163
Pathological type (adenocarcinoma vs. others)	0.007	0.489	0.289-0.826	0.402	0.774	0.425-1.410
Differentiation (poor vs. well)	<0.001	0.435	0.305-0.620	0.078	0.690	0.457-1.043
Vascular invasion (negative vs. positive)	<0.001	2.219	1.528-3.225	0.227	1.329	0.837-2.110
Nerve invasion (negative vs. positive)	<0.001	2.538	1.753-3.676	0.290	1.278	0.812-2.010
Cancerous node (negative vs. positive)	<0.001	3.459	1.804-6.630	0.071	2.115	0.938-4.769
TNM stage (I+II vs. III+IV)	<0.001	5.517	3.292-8.077	<0.001	3.508	2.007-6.131
CEA (≤2.17 ng/mL vs. >2.17 ng/mL)	<0.001	2.050	1.400-3.003	0.009	1.856	1.167-2.951
CA19-9 (≤41.10 U/mL vs. >41.10 U/mL)	<0.001	2.686	1.892-3.805	0.031	1.639	1.046-2.567
Fibrinogen (≤2.97 g/L vs. >2.97 g/L)	<0.001	2.160	1.461-3.194	0.044	1.629	1.014-2.618

Note: HR: hazard ratio; CI: confidence interval; BMI: body mass index; CEA: carcinoembryonic antigen; CA19-9: carbohydrate antigen 19-9.