The Prognostic Value of Preoperative Fibrinogen in Patients with Radical Cholecystectomy

Table 3

Univariate and multivariate analyses of OS in patients with GBC.

Factors	Univariate analysis			Multivariate analysis
	value	HR	95% CI	value	HR	95% CI
Gender (male vs. female)	0.435	1.178	0.781-1.778
Age (≤60 vs. >60)	0.566	1.1400	0.729-1.782
BMI (≤22.62 vs. >22.62)	0.778	1.073	0.657-1.752
Smoking history (no vs. yes)	0.349	1.270	0.770-2.095
Drinking history (no vs. yes)	0.493	1.167	0.750-1.815
Tumor location (body+fundus vs. neck)	0.002	2.069	1.320-3.241	0.042	1.701	1.019-2.841
Tumor size (≤3.5 cm vs. >3.5 cm)	0.401	1.046	0.942-1.161
Pathological type (adenocarcinoma vs. others)	0.001	0.382	0.220-0.663	0.211	0.665	0.352-1.259
Differentiation (poor vs. well)	<0.001	0.343	0.224-0.524	0.017	0.556	0.343-0.902
Vascular invasion (negative vs. positive)	<0.001	2.174	1.143-3.345	0.197	1.397	0.840-2.322
Nerve invasion (negative vs. positive)	<0.001	2.410	1.599-3.632	0.871	0.958	0.575-1.599
Cancerous node (negative vs. positive)	<0.001	4.277	2.143-8.537	0.009	3.529	1.378-9.038
TNM stage (I+II vs. III+IV)	<0.001	5.265	3.074-9.016	0.001	2.985	1.551-5.746
CEA (≤2.17 ng/mL vs. >2.17 ng/mL)	0.001	2.318	1.452-3.700	0.025	1.880	1.081-3.271
CA19-9 (≤41.10 U/mL vs. >41.10 U/mL)	<0.001	2.851	1.902-4.274	0.104	1.516	0.918-2.503
Fibrinogen (≤2.97 g/L vs. >2.97 g/L)	<0.001	3.021	1.812-5.038	0.006	2.328	1.272-4.261

Note: HR: hazard ratio; CI: confidence interval; BMI: body mass index; CEA: carcinoembryonic antigen; CA19-9: carbohydrate antigen 19-9.