Assessment of Ameliorative Effect of Myrica esculenta in a DSS-Induced Murine Model against Ulcerative Colitis

Figure 3

Effect of MeEt extract on colon and spleen tissues against DSS-induced UC in mice. UC was induced in all the groups except vehicle control group by treating animals with the DSS (3%) in drinking water for 7 days. Mesalazine/MSZ (100 mg/kg BW) was administered orally as a standard drug. MeEt extract was administered orally at the doses of 200 and 400 mg/kg BW once a day for 7 days. Animals from all the groups were scarified after 24 h of the last dose, and colons were harvested: (a) group-wise images of colon, harvested on day 7; (b) colon length; (c) colon weight/length ratio (mg/cm); (d) spleen weight (g). All data are presented as (). Tukey’s multiple comparison test along with a one-way ANOVA was utilized to identify the significant differences among the groups. ^###, ^##, and ^#, DSS control group vs. vehicle control group; , , and , treatment groups vs. DSS control group.

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