Assessment of Ameliorative Effect of Myrica esculenta in a DSS-Induced Murine Model against Ulcerative Colitis

Figure 4

Effect of MeEt extract on the production of inflammatory cytokines in (a) serum and (b) colon tissues against DSS-induced UC in mice. Determination of cytokine production was done by ELISA. UC was induced in all the groups except vehicle control group by treating animals with the DSS (3%) in drinking water for 7 days. Mesalazine/MSZ (100 mg/kg BW) was administered orally as a standard drug. MeEt extract was administered orally at the doses of 200 and 400 mg/kg BW once a day for 7 days. (A) IL6 (pg/mL); (B) IL8 (pg/mL); (C) IL10 (pg/mL); (D) IL1β (pg/mL); (E) TNFα (pg/mL); (F) IFN-γ (pg/mL) production in colon tissue on day 7. All data are presented as (). Tukey’s multiple comparison test along with a one-way ANOVA was utilized to identify the significant differences among the groups. ^###, ^##, and ^#, DSS control group vs. vehicle control group; , , and , treatment groups vs. DSS control group.