Assessment of Ameliorative Effect of Myrica esculenta in a DSS-Induced Murine Model against Ulcerative Colitis

Figure 6

Microscopic analysis of colon tissue sections stained with H&E: (a) vehicle control group showing the normal architecture of colon with rare or no observation of inflammatory cells; (b) DSS control group showing degenerated and abnormal epithelium; (c) MSZ at 100 mg/kg BW treated group showing significant amelioration of inflammatory cell accumulation and protection as compared to DSS control group; (d) MeEt at 200 mg/kg BW showing less significant protection of epithelium as compared to DSS control group; (e) MeEt at 400 mg/kg BW showing moderate protection of epithelium as well as reduced inflammatory cell accumulation as compared to DSS control group. (f) Data of the histological analysis has been reported as colonic histopathological score, whereby the degree of colonic inflammation was scored semiquantitatively. All data are presented as (). Tukey’s multiple comparison test along with a one-way ANOVA was utilized to identify the significant differences among the groups. ^###, ^##, and ^#, DSS control group vs. vehicle control group; , , and , treatment groups vs. DSS control group.

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