Complex Variant t(9;22) Chromosome Translocations in Five Cases of Chronic Myeloid Leukemia

Table 2

Cytogenetic and molecular results.

Case	Karyotype	5^′ ABL deletions	RT-PCR	BCR-ABL/ABL (%) diagnosis	BCR-ABL/ABL (%) after imatinib
(a)	46, XY, t(5;9;22)(q31;q34;q11)[5]/45, X, idem, −Y[4]/46, X, idem, +8[3]/46, XY, +8, t(5;9;22)[2]/46, XY, −4, t(5;9;22), −7, +der(X)? t(X;1)(p11.4;q21), +mar[6]	NO	b3a2	11.09	0.11
(b)	46, XX, t(9;22;10)(q34;q11;q22)[20]	NO	b3a2	1.75	0.014
(c)	46, XX, t(7;9;22)(q34;q11;q32)[25]	NO	b3a2	13.56	0.004
(d)	45, XY, t(3;9;22)(q21;q34;q11), −15[4]/46, XY, idem, +22[4]/46, XY[1]	NO	b3a2	11.06	Negative
(e)	46, XX, t(8;9;22)(q24.1;q34;q11)[20]	NO	b3a2	N.A	Negative