Highly Elevated Serum Hepcidin in Patients with Acute Myeloid Leukemia prior to and after Allogeneic Hematopoietic Cell Transplantation: Does This Protect from Excessive Parenchymal Iron Loading?

Table 1

Patient characteristics at baseline (𝑛=42).

Parameters	Results
Mean age, years (range)	57 (18–70)
Gender, 𝑛 (%)
Male	23 (54.8)
Female	19 (45.2)
Donor, 𝑛 (%)
MRD	8 (19%)
MUD	34 (81%)
Conditioning, 𝑛 (%)
Conventional	13 (31.0)
RIC	29 (69.0)
Acute GVHD, 𝑛 (%)
Skin
No	7 (16.7)
Yes	35 (83.3)
Grade I	21
Grade II	10
Grade III	4
Liver
No	35 (83.3)
Yes	7 (16.7)
Grade I	6
Grade II	1
Grade III	0
Median number of blood transfusions (range)
Prior to HCT	22 (8– 95)
After HCT	30 (14–120)
Median serum ferritin (range) ng/mL
Prior to HCT	1945 (617–6981)
After HCT	2260 (807–7595)
Median serum hepcidin (range) ng/mL
Prior to HCT	358 (56–1096 )
After HCT	398 (172–941)

MRD: matched related donor; MUD: matched unrelated donor; RIC: reduced intensity conditioning; GVHD: graft versus host disease; HCT: hematopoietic stem cell transplantation.