Review Article
Pathogenetic, Clinical, and Prognostic Features of Adult t(4;11)(q21;q23)/MLL-AF4 Positive B-Cell Acute Lymphoblastic Leukemia
Table 2
Cytogenetic molecular classification of adult ALL based on more recently published data.
| | Risk group | Chromosomal/molecular aberrations | 5y-DFS | 5y-OS |
| | STANDARD-RISK | Isolated 9p/p15-p16 deletions
High hyperdiploidy
Normal karyotype/no molecular aberrations | 35–68% | 48–80% |
| | INTERMEDIATE-RISK | del(6q)
Trisomy of chromosome 21
Trisomy of chromosome 8
t(1;19)/E2A-PBX | 37–51% | 35–40% |
| | HIGH-RISK | t(9;22)/BCR-ABL
t(4;11)/MLL-AF4
11q23 MLL rearrangements
Monosomy of chromosome 7
Low hypodiploidy/near triploidy
Complex karyotype
High BAALC expression
Aberrations of IKZF1 gene | 10–52% | 15–35% |
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CR: complete remission; 5y-DFS: 5 years disease-free survival; 5y-OS: 5 years overall survival.
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