Exploring Risk Factors for Follicular Lymphoma

Table 2

Aspects of the medical history and genetic factors associated with FL.

Exposure	Measured effect (95% CI)	Reference
Medical Hx
Hepatitis history	OR = 0.36 (0.17–0.74)	[37]
History of heart disease	OR = 1.5 (1.0–2.1)	[37]
3 or more bee stings	OR = 0.79 (0.62–1.0)	[37]
Gallstones	OR = 0.71 (0.33–1.52)	[36]
Hypertension	OR = 0.92 (0.63–1.94)	[36]
DM, no treatment	OR = 2.53 (0.57–11.2)	[36]
Sjogren's syndrome	OR = 3.91 (1.39–11.0)	[42]
History of transfusion	OR = 1.40 (0.87–2.26)	[40]
Medical indication for first transfusion (ref = Trauma)	OR = 3.07 (1.18–7.98)	[40]
Any anesthesia (24+)	OR = 1.49 (0.76–2.91)	[40]
Total number of surgeries (26+)	OR = 1.92 (0.97–3.78)	[40]
Pharmaceuticals and vaccinations
Polio vaccination	OR = 0.54 (0.31–0.92)	[43]
Influenza vaccination	OR= 1.98 (1.23–3.18)	[43]
NSAID use	OR = 0.67 (0.44–1.00)	[37]
Non-insulin diabetes mellitus treatment	OR = 0.29 (0.1–0.82)	[37]
Beta blockers	OR = 2.5 (0.9–7.0)	[37]
DM, no treatment	OR = 2.53 (0.57–11.2)	[36]
DM, oral treatment	OR = 0.46 (0.61–1.35)	[36]
DM, insulin	OR = 0.63 (0.14–2.92)	[36]
Calcium channel blocker use	OR = 1.08 (0.60–1.94)	[36]
Diuretic use	OR = 0.83 (0.48–1.44)	[36]
Allergies
General Hx of allergies	OR = 0.7 (0.5–1.0)	[61]
Hay fever	OR = 0.7 (0.5–1.1)	[61]
Eczema alone	OR =1.9 (1.1–3.4)	[61]
Molecular
SNPs within the MHC region, 6p21.32
rs10484561	OR = 1.95 (1.72–2.22)	[77]
rs7755224	OR = 2.07 (1.76–2.42)	[77]
Haplotype HLA-DRB1* 0101-HLA-DQA1*0101-HLA-DQB1* 0501	OR = 2.07 (1.40–3.06)	[77]
SNPs within DNA repair genes
ERCC2	No association	[78]
XRCC1	No association	[78]
XRCC3_Rs3212024	OR = 1.8 (1.1–2.8)	[78]
XRCC3_Rs3212038	OR = 1.5 (1.0–2.4)	[78]
XRCC3_Rs3212090	OR = 1.5 (1.0–2.5)	[78]